SINCE World War II, medical science has progressed with a stage where competitive medications are around for treat the identical ailment in different people. This is not nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall look at the various factors that decide picking a a particular drug.

Safety: The subsequent sub-criteria has to be considered within the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug even though it’s certain side-effects provided that the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the possible side-effect of addiction.

* Long-term safety: medicine directory could be safe in short-term treatment, but how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Drugs are chemicals, and several chemicals answer produce a different chemical, which has an effect that could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from each other, have certain effects on one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by due to the metabolism. This causes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually generate the same effect on the identical organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the medicines are more serious.

Tolerability: A drug could be effective however, not tolerable by all patients. Example: Allergies to a particular drugs in some people. Short-term and long-term tolerability have to be taken into consideration. Efficacy: A drug is not equally great at all patients. By way of example, some patients with depression or panic attacks experience respite from escitalopram, but there are lots of who don’t, who therefore have to be prescribed an alternative anti-depressant. The speed of oncoming of therapeutic action is a crucial step to be regarded too.

Cost: Cost does not mean the price of acquiring some medicine alone. It must also cover the price of treatment of a complication that could arise from utilizing an alternative drug. Example: In the individual that insists on taking alcohol yet should be treated for depression is often administered an SSRI drug because they drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (such as tricyclics) might cause a brand new condition in such patients, which may have to have a various and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram instead of a cheaper tricyclic in such patients.

Simple treatment: Most effective mode of administration is preferred. If you find a choice between a shot and oral administration, the second is preferred when the efficacy of the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are key point to decide simplicity of treatment.
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