SINCE World War II, medical science has progressed to some stage where competitive medications are around to treat the same ailment in several people. This is simply not nearly brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall look at the various factors that decide your selection of a specific drug.

Safety: These sub-criteria must be considered under the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective is a particular drug even when it’s got certain side-effects providing the acuteness from the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the possibility side-effect of addiction.

* Long-term safety: drug directory could possibly be safe in short-term treatment, so how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals react to produce a different chemical, that have an effect that could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other person, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This makes a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually create the same impact on the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the two medicines are more serious.

Tolerability: A medicine could possibly be effective although not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability must be looked at. Efficacy: A medicine just isn’t equally effective in all patients. As an example, some patients with depression or anxiety disorders experience rest from escitalopram, but there are numerous that don’t, who therefore must be prescribed another anti-depressant. The pace of start of therapeutic action is a the answer to be regarded too.

Cost: Cost does not always mean the price of acquiring a specific medicine alone. It ought to also cover the price of management of a complication that could arise by using another drug. Example: In a individual who insists on taking alcohol and yet must be treated for depression is usually administered an SSRI drug because they drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (including tricyclics) may cause a fresh symptom in such patients, which could require a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than a cheaper tricyclic in such patients.

Simple treatment: The best mode of administration is preferred. If you have a selection between a shot and oral administration, the latter is preferred if your efficacy of the two modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key point to choose simple treatment.
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