SINCE Wwii, medical science has progressed to a stage where competitive medications are available to treat precisely the same ailment in different people. This isn’t almost brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall consider the various factors that decide your selection of a specific drug.

Safety: The subsequent sub-criteria have to be considered beneath the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective is a particular drug even when they have certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the potential side-effect of addiction.

* Long-term safety: drug directory may be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and many chemicals respond to make a different chemical, that have an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of 2 types:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from one another, have certain effects one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This causes a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, a couple of drugs actually generate the same impact on precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the prescription medication is more serious.

Tolerability: A medication may be effective although not tolerable by all patients. Example: Allergies to a particular drugs in most people. Short-term and long-term tolerability must be considered. Efficacy: A medication isn’t equally efficient at all patients. For instance, some patients with depression or anxiety disorders experience reduced escitalopram, but there are several that do not, who therefore must be prescribed some other anti-depressant. The speed of oncoming of therapeutic action is an important key to be considered too.

Cost: Cost doesn’t imply the expense of acquisition of a certain medicine alone. It should also cover the expense of management of a complication that may arise from using some other drug. Example: In the one who insists on taking alcohol yet has to be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (like tricyclics) can cause a new problem in such patients, which could demand a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram instead of a cheaper tricyclic in this patients.

Simplicity of treatment: The easiest mode of administration is preferred. If there is a selection between an injection and oral administration, rogues is preferred in the event the efficacy of both the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to determine simplicity of treatment.
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