SINCE Wwii, medical science has progressed to a stage where competitive medications are available to treat exactly the same ailment in different people. It’s not just about brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall glance at the various factors that decide your selection of a specific drug.

Safety: The subsequent sub-criteria has to be considered underneath the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug regardless of whether it’s certain side-effects provided that the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but include the opportunity side-effect of addiction.

* Long-term safety: directory may be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Drugs are chemicals, and a lot of chemicals react to develop a different chemical, that have an effect that will harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other person, have certain effects one or maybe more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for the metabolism. This makes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually produce the same influence on exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the prescription medication is more serious.

Tolerability: A medicine may be effective but not tolerable by all patients. Example: Allergies to certain drugs in some people. Short-term and long-term tolerability should be considered. Efficacy: A medicine is not equally efficient at all patients. By way of example, some patients with depression or anxiety attacks experience rest from escitalopram, but there are numerous who don’t, who therefore should be prescribed a different anti-depressant. The speed of beginning of therapeutic action is a vital key to be regarded as too.

Cost: Cost doesn’t imply the price tag on purchase of a particular medicine alone. It should also cover the price tag on treatment of a complication that will arise from using a different drug. Example: In a one who insists on taking alcohol nevertheless must be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another band of anti-depressants (including tricyclics) might cause a fresh symptom in such patients, which will have to have a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram instead of a cheaper tricyclic in this patients.

Simple treatment: The easiest mode of administration is preferred. If you find an alternative between an injection and oral administration, the latter is preferred when the efficacy of the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to make a decision simple treatment.
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