SINCE Wwii, medical science has progressed to some stage where competitive medications are available to treat the same ailment in numerous people. This is simply not pretty much brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall glance at the various factors that decide the selection of a specific drug.

Safety: These sub-criteria must be considered underneath the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective is often a particular drug even though they have certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers work well in healing pain but include the possibility side-effect of addiction.

* Long-term safety: medicine may be safe in short-term treatment, but exactly how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case there is prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and a lot of chemicals answer make a different chemical, that have an effect that will harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of each other, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This makes a boost in the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually create the same impact on the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the prescription medication is more serious.

Tolerability: A medicine may be effective however, not tolerable by all patients. Example: Allergies to particular drugs in a few people. Short-term and long-term tolerability have to be considered. Efficacy: A medicine just isn’t equally good at all patients. As an example, some patients with depression or panic attacks experience reduced escitalopram, but there are many that don’t, who therefore have to be prescribed an alternative anti-depressant. The interest rate of beginning of therapeutic action is a step to be regarded too.

Cost: Cost doesn’t imply the price of buying a certain medicine alone. It will also cover the price of treatment of a complication that will arise by using an alternative drug. Example: In the individual who insists on taking alcohol nevertheless must be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (including tricyclics) may cause a brand new overuse injury in such patients, which may have to have a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than cheaper tricyclic such patients.

Simple treatment: The best mode of administration is preferred. If you have an option between an injection and oral administration, the latter is preferred if your efficacy of the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to determine simplicity of treatment.
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