SINCE World war 2, medical science has progressed to a stage where competitive medications are around for treat exactly the same ailment in different people. This is simply not nearly brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall consider the various factors that decide your selection of a selected drug.

Safety: The next sub-criteria must be considered under the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even if it’s certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the possibility side-effect of addiction.

* Long-term safety: medicine could possibly be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals react to make a different chemical, which has an effect which could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of the other person, have certain effects on one or even more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon due to the metabolism. This causes a boost in the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually produce the same influence on exactly the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both drugs are more serious.

Tolerability: A medicine could possibly be effective although not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability should be taken into account. Efficacy: A medicine is just not equally great at all patients. For example, some patients with depression or panic attacks experience rest from escitalopram, but there are lots of who don’t, who therefore should be prescribed another anti-depressant. The pace of start of therapeutic action is a step to be looked at too.

Cost: Cost doesn’t imply the price of purchase of some medicine alone. It must also cover the price of treatment of a complication which could arise by using another drug. Example: In the individual who insists on taking alcohol but must be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (including tricyclics) might cause a brand new overuse injury in such patients, which may have to have a various and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than a cheaper tricyclic such patients.

Simple treatment: The simplest mode of administration is preferred. If there is a selection between a shot and oral administration, rogues is preferred if your efficacy of both modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key point to determine simple treatment.
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