SINCE The second world war, medical science has progressed with a stage where competitive medications are for sale to treat the same ailment in different people. This is not nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). On this report, we shall consider the various factors that decide selecting a selected drug.

Safety: The next sub-criteria must be considered underneath the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is a particular drug even if it has certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the opportunity side-effect of addiction.

* Long-term safety: http://medicationdirectory.com may be safe in short-term treatment, but exactly how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and many chemicals reply to create a different chemical, which has an effect which could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of 2 types:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from each other, have certain effects one or higher body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon due to the metabolism. This leads to a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, a couple of drugs actually generate the same impact on the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the medicine is more intense.

Tolerability: A medication may be effective although not tolerable by all patients. Example: Allergies to certain drugs in some people. Short-term and long-term tolerability have to be taken into account. Efficacy: A medication is not equally effective in all patients. As an example, some patients with depression or panic attacks experience relief from escitalopram, but there are several that do not, who therefore have to be prescribed another anti-depressant. The pace of onset of therapeutic action is a vital factor to be regarded too.

Cost: Cost doesn’t imply the cost of purchase of a particular medicine alone. It ought to also cover the cost of treatment of a complication which could arise while using another drug. Example: Within a one who insists on taking alcohol nevertheless should be treated for depression is usually administered an SSRI drug because they drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (including tricyclics) can cause a new symptom in such patients, which may have to have a various and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram rather than cheaper tricyclic in such patients.

Simple treatment: The easiest mode of administration is preferred. If there is a choice between a shot and oral administration, the latter is preferred when the efficacy of the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are key point to decide simplicity of treatment.
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