SINCE The second world war, medical science has progressed with a stage where competitive medications are available to treat the same ailment in various people. This is not nearly brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall consider the various factors that decide your selection of a specific drug.

Safety: The next sub-criteria should be considered beneath the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective is really a particular drug even though they have certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but include the opportunity side-effect of addiction.

* Long-term safety: drug may be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals answer produce a different chemical, which has an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.

Drug-drug interaction risk is of 2 types:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from each other, have certain effects on one or even more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for the metabolism. This makes a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually make the same influence on the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two prescription medication is more serious.

Tolerability: A medication may be effective but not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability need to be considered. Efficacy: A medication isn’t equally great at all patients. For instance, some patients with depression or anxiety disorders experience respite from escitalopram, but there are many that do not, who therefore need to be prescribed a different anti-depressant. The rate of oncoming of therapeutic action is a vital step to be considered too.

Cost: Cost does not mean the expense of buying a specific medicine alone. It must also cover the expense of treatments for a complication that will arise from using a different drug. Example: Within a person who insists on taking alcohol but needs to be treated for depression is usually administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (like tricyclics) might cause a fresh symptom in such patients, which would have to have a various and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic such patients.

Simplicity of treatment: The easiest mode of administration is preferred. When there is an option between an injection and oral administration, aforementioned is preferred when the efficacy of the two modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key point to determine simplicity of treatment.
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